SINTESIS DAN IDENTIFIKASI STRUKTUR SENYAWA 3-(3,5-DINITROBENZOIL)-1-FENILTIOUREA SEBAGAI KANDIDAT ANTIKANKER

Susanti Susanti, Ruswanto Ruswanto, Muharam Priatna

Abstract


Thiourea derivatives are known to be potential anticancer agents. 3-(3,5-dinitrobenzoyl)-1-
phenylthiourea as a thiourea derivatives has been synthesized through acylation between 3,5-
dinitrobenzoyl chloride and 1-phenylthiourea in tetrahydrofuran with triethylamine as
catalyst through reflux process with stirring for 6 hours. The percentage of yield was
13,86%. The purity of the product was shown by the single spot on the TLC and narrow
range of melting point. The structure identification results with UV spectrophotometry, IR
spectroscopy and 1HNMR spectroscopy showed that the structure of the product was
appropriate to the prediction.


Full Text:

PDF

References


Huhtiniemi, et al. 2008. Oxadiazolecarbonylaminothioureas as SIRT1 dan SIRT2 inhibitors. J Med Chem Vol. 14;51(15):4377-80.

Jian Li, et al. 2006. Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives. Acta Pharmacologica Sinica, Vol. 27 (9): 1259–1271.

Kesuma, Dini., Harry Santosa. 2009. Sintesis Senyawa 2,4-

diklorobenzoiltiourea dari 2,4-diklorobenzoil klorida dan Tiourea Sebagai Calon Obat Central Nervous System Depressant Melalui Proses Refluks. Seminar Nasional Teknik Kimia Indonesia, SNTKI 2009.

Maharani, Sabrina. 2012. Kanker: Mengenal 13 Jenis Kanker dan

Pengobatannya. Yogyakarta: Katahati. Hal. 11.

Pudjono, et al. 2002. Sintesis Dibenzoil Resorsinol dari Benzoil Klorida dan Resorsinol melalui Modifikasi Metode Schotten-Baumann. Sigma, Vol.5 No. 1 : 61-68.

Silverstein, R.M., Bassler, G.C., and Morrill, T.C. 1981. SpectrometricIdentification of Organic Compound 4th Ed. John Wiley and Sons Inc.,New York.

Siswandono., Bambang Soekardjo. 2000. Kimia Medisinal Jilid 1. Surabaya: Airlangga University Press. Hal. 5-6.

Souza, Estevez., et al. 2006. Synthesis, cytotoxicity, and DNAtopoisomerase inhibitory activity of new asymmetric ureas and thioureas. Bioorg Med Chem, Vol. 14(2):492-9.

Supratman, Unang. 2010. Elusidasi Struktur Senyawa Organik.

Bandung: Widya Padjadjaran. Hal. 1; 10; 66; 117; 260.




DOI: https://doi.org/10.36423/pharmacoscript.v1i1.102

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 Susanti Susanti, Ruswanto Ruswanto, Muharam Priatna

Pharmacoscript is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

View My Stats